26 results
The genetic contribution to the comorbidity of depression and anxiety: a multi-site electronic health records study of almost 178 000 people
- Brandon J Coombes, Isotta Landi, Karmel W Choi, Kritika Singh, Brian Fennessy, Greg D Jenkins, Anthony Batzler, Richard Pendegraft, Nicolas A Nunez, Y Nina Gao, Euijung Ryu, Priya Wickramaratne, Myrna M Weissman, Regeneron Genetics Center, Jyotishman Pathak, J John Mann, Jordan W Smoller, Lea K Davis, Mark Olfson, Alexander W Charney, Joanna M Biernacka
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- Journal:
- Psychological Medicine / Volume 53 / Issue 15 / November 2023
- Published online by Cambridge University Press:
- 05 May 2023, pp. 7368-7374
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Background
Depression and anxiety are common and highly comorbid, and their comorbidity is associated with poorer outcomes posing clinical and public health concerns. We evaluated the polygenic contribution to comorbid depression and anxiety, and to each in isolation.
MethodsDiagnostic codes were extracted from electronic health records for four biobanks [N = 177 865 including 138 632 European (77.9%), 25 612 African (14.4%), and 13 621 Hispanic (7.7%) ancestry participants]. The outcome was a four-level variable representing the depression/anxiety diagnosis group: neither, depression-only, anxiety-only, and comorbid. Multinomial regression was used to test for association of depression and anxiety polygenic risk scores (PRSs) with the outcome while adjusting for principal components of ancestry.
ResultsIn total, 132 960 patients had neither diagnosis (74.8%), 16 092 depression-only (9.0%), 13 098 anxiety-only (7.4%), and 16 584 comorbid (9.3%). In the European meta-analysis across biobanks, both PRSs were higher in each diagnosis group compared to controls. Notably, depression-PRS (OR 1.20 per s.d. increase in PRS; 95% CI 1.18–1.23) and anxiety-PRS (OR 1.07; 95% CI 1.05–1.09) had the largest effect when the comorbid group was compared with controls. Furthermore, the depression-PRS was significantly higher in the comorbid group than the depression-only group (OR 1.09; 95% CI 1.06–1.12) and the anxiety-only group (OR 1.15; 95% CI 1.11–1.19) and was significantly higher in the depression-only group than the anxiety-only group (OR 1.06; 95% CI 1.02–1.09), showing a genetic risk gradient across the conditions and the comorbidity.
ConclusionsThis study suggests that depression and anxiety have partially independent genetic liabilities and the genetic vulnerabilities to depression and anxiety make distinct contributions to comorbid depression and anxiety.
338 The Alabama Genomic Health Initiative: Integrating Genomic Medicine into Primary Care
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- Nita A Limdi, Devin Absher, Irf Asif, Lori Bateman, Greg Barsh, Kevin M. Bowling, Gregory M. Cooper, Brittney H. Davis, Kelly M. East, Candice R. Finnila, Blake Goff, Susan Hiatt, Melissa Kelly, Whitley V. Kelley, Bruce R. Korf, Donald R. Latner, James Lawlor, Thomas May, Matt Might, Irene P. Moss, Mariko Nakano-Okuno, Tiffany Osborne, Stephen Sodeke, Adriana Stout, Michelle L. Thompson
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue s1 / April 2023
- Published online by Cambridge University Press:
- 24 April 2023, pp. 100-101
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OBJECTIVES/GOALS: Supported by the State of Alabama, the Alabama Genomic Health Initiative (AGHI) is aimed at preventing and treating common conditions with a genetic basis. This joint UAB Medicine-HudsonAlpha Institute for Biotechnology effort provides genomic testing, interpretation, and counseling free of charge to residents in each of Alabama’s 67 counties. METHODS/STUDY POPULATION: Launched in 2017, as a state-wide population cohort, AGHI (1.0) enrolled 6,331 Alabamians and returned individual risk of disease(s) related to the ACMG SF v2.0 medically actionable genes. In 2021, the cohort was expanded to include a primary care cohort. AGHI (2.0) has enrolled 750 primary care patients, returning individual risk of disease(s) related to the ACMG SF v3.1 gene list and pre-emptive pharmacogenetics (PGx) to guide medication therapy. Genotyping is done on the Illumina Global Diversity Array with Sanger sequencing to confirm likely pathogenic / pathogenic variants in medically actionable genes and CYP2D6 copy number variants using Taqman assays, resulting in a CLIA-grade report. Disease risk results are returned by genetic counselors and Pharmacogenetics results are returned by Pharmacists. RESULTS/ANTICIPATED RESULTS: We have engaged a statewide community (>7000 participants), returning 94 disease risk genetic reports and 500 PGx reports. Disease risk reports include increased predisposition to cancers (n=38), cardiac diseases (n=33), metabolic (n=12), other (n=11). 100% of participants harbor an actionable PGx variant, 70% are on medication with PGx guidance, 48% harbor PGx variants and are taking medications affected. In 10% of participants, pharmacists sent an active alert to the provider to consider/ recommend alternative medication. Most commonly impacted medications included antidepressants, NSAIDS, proton-pump inhibitors and tramadol. To enable the EMR integration of genomic information, we have developed an automated transfer of reports into the EMR with Genetics Reports and PGx reports viewable in Cerner. DISCUSSION/SIGNIFICANCE: We share our experience on pre-emptive implementation of genetic risk and pharmacogenetic actionability at a population and clinic level. Both patients and providers are actively engaged, providing feedback to refine the return of results. Real time alerts with guidance at the time of prescription are needed to ensure future actionability and value.
9-1-1 Caller-Described Heart Attack Symptoms
- Greg Scott, Christopher Olola, Matthew Miko, Brett Patterson, Joleen Quigg, Chris Davis, Richard Lindfors, Jayme Tidwell, Kevin Pagenkop, John Lofgren, Jaci Fox, Jeff Clawson
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- Journal:
- Prehospital and Disaster Medicine / Volume 37 / Issue 5 / October 2022
- Published online by Cambridge University Press:
- 18 July 2022, pp. 609-615
- Print publication:
- October 2022
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Introduction:
Heart attacks (HAs) present clinically with varying symptoms, which are not always described by patients as chest pain (CP) or chest discomfort (CD). Emergency Medical Dispatchers (EMDs) select the CP/CD dispatch protocol for non-chest pain HA symptoms or classic HA complaint of CP/CD. Nevertheless, it is still unknown how often callers report HA symptoms other than CP/CD.
Objectives:The objective of this study was to characterize the caller’s descriptions of the primary HA symptoms, descriptions of the other HA symptoms, and the use of a case entry (CE) question clarifier.
Methods:A retrospective descriptive study analyzed randomly selected EMD audios (where CD/CD protocol was used) from five accredited emergency communication centers in the United States. Several Quality Performance Review (QPR) experts reviewed the audios and recorded callers’ initial problem descriptions, the use of and responses to the CE question clarifier, including the EMD-assigned final determinant code.
Results:A total of 1,261 audios were reviewed. The clarifier was used only 8.5% of the time. The CP/CD symptoms were mentioned alone or with other problems 87.0% of the time. Overall, CP symptom was mentioned alone 70.8%, HA alone 4.0%, and CD symptom alone 1.4% of the time.
Conclusion:9-1-1 callers report potential HA cases using a variety of terms and descriptions—most commonly CP. Other less-common symptoms associated with a HA may be mentioned. Therefore, EMDs must be well-trained to be prepared to probe the caller with a clarifying query to elicit more specific information when “having a heart attack” is the only complaint initially mentioned.
Correlative In Operando Studies of Abusive Cycling Conditions for Li-ion Batteries
- Jeung Hun Park, Abhi Raj, Andrew Kim, Greg Davies, Dan Steingart
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- Journal:
- Microscopy and Microanalysis / Volume 24 / Issue S1 / August 2018
- Published online by Cambridge University Press:
- 01 August 2018, pp. 1910-1911
- Print publication:
- August 2018
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28 - Tier 4 options
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- By Tim McDougall, Cheshire & Wirral NHS Foundation Trust, Anne Worrall-Davies, University of Leeds, Lesley Hewson, Bradford District Care Trust, Rosie Beer, Greg Richardson, North Yorkshire & York Primary Care Trust
- Edited by Greg Richardson, Ian Partridge, Jonathan Barrett
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- Book:
- Child and Adolescent Mental Health Services
- Published by:
- Royal College of Psychiatrists
- Published online:
- 25 February 2017, pp 259-269
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Summary
‘Two roads diverged in a wood, and I–
I took the one less travelled by,
And that has made all the difference.’
Robert Frost (1874–1963)Introduction
Tier 4 CAMHS aim to meet the needs of children and young people with the most complex, severe or persistent mental health problems. Tier 4 services include in-patient care (see Chapter 29), as well as a range of day care and intensive community home-based and outreach services for specific groups of children and young people.
Day services
Early descriptions of child and adolescent mental health day units emphasised 5-day ‘milieu’ provision with a strong emphasis on education and behaviour management (Brown, 1996), whereas now they frequently provide daily focused activities to which children and families are invited, depending on their needs. Currently, about half of UK day services are linked to in-patient units, and many in-patient units have a day programme (Green & Jacobs, 1998). It is impossible to classify day services owing to the enormous range in milieu and interventions provided (Green & Worrall- Davies, 2008). However, day services broadly offer:
• support and transition to community services following in-patient admission;
• intensive 5 days per week treatment packages for children and their families;
• treatment of disruptive behaviour, using multimodal treatment strategies with a combination of individual, family and psychopharmacological interventions;
• specialist management and programmes of care for younger children with developmental disorders such as autism, speech and language disorders or neuropsychiatric disorders;
• intensive intervention aimed at improving family functioning in situations of family breakdown or child maltreatment.
Provision and organisation
Day units can offer assessment and therapeutic services that are more specialised, complex and intensive than out-patient services, although they are still community-based and less disruptive than in-patient admission. Most also have the benefit of educational input. Close liaison with specialised education and Social Services is central to their work. There is general acceptance of the central importance of maintaining attachments and working with whole systems if the complex needs of children are to be met. Day units can work with children and young people individually and in groups, as well as with their families, while keeping the focus of concern within the community and avoiding the ‘out of sight, out of mind’ dilemma of in-patient services.
29 - In-patient psychiatric care
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- By Angela Sergeant, Leigh House Hospital, Winchester, Greg Richardson, North Yorkshire & York Primary Care Trust, Ian Partridge, Lime Trees CAMHS, York, Tim McDougall, Cheshire & Wirral NHS Foundation Trust, Anne Worrall-Davies, University of Leeds, Lesley Hewson, Bradford District Care Trust
- Edited by Greg Richardson, Ian Partridge, Jonathan Barrett
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- Book:
- Child and Adolescent Mental Health Services
- Published by:
- Royal College of Psychiatrists
- Published online:
- 25 February 2017, pp 270-283
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Summary
‘“It all comes”, said Pooh crossly, “of not having front doors big enough.”’
A. A. Milne, Winnie the PoohIntroduction
Despite the development of home treatment teams and early intervention psychosis services, the demand for in-patient child and adolescent beds remains. It is rare for young people with mental disorders to require inpatient services, but when they do, beds are few and far between. Reasons for admission include severity of illness, deterioration in psychological functioning despite community treatment, high risk to self or others, or family difficulties making treatment difficult, any of which may lead to the need for 24-hour care (Green & Worrall-Davies, 2008). In-patient care is a specialised field providing treatment for young people with serious psychiatric illness by skilled and experienced staff.
Who and what are in-patient units for?
There is a range of psychiatric, educational, social, criminal and societal indicators for admission to an in-patient service. It is usually impossible to separate the different aspects or contributors to the young person's disorder so that each can be provided by the different agencies responsible for it. Psychological disorders, because of adverse life experiences, are common and pure psychiatric disorders are rare, but they all have educational and social precursors and sequelae. Trying to compartmentalise children into unidisciplinary treatment pigeonholes is problematic as:
• admission to psychiatric in-patient units considerably disrupts education and the young person's functioning in the community
• education authorities have to meet young people's special educational needs but cannot isolate these from other social and mental health factors, which they often do not have the resources to address
• residential policies of Social Services departments tend to address young people's mental health and educational needs only as secondary considerations
• the Home Office and Ministry of Justice, which will provide care in a prison setting, have little investment in childhood preventative work for the large proportion of young people with conduct disorder and complex needs when they become adults.
Work on sharing residential responsibility and input requires considerable inter-departmental and inter-agency working, but each agency will be uncertain who is going to reap the most for investing in them, and the harvest is not guaranteed.
Control of Horseweed (Conyza canadensis) with Growth Regulator Herbicides
- Greg R. Kruger, Vince M. Davis, Stephen C. Weller, William G. Johnson
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- Journal:
- Weed Technology / Volume 24 / Issue 4 / December 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 425-429
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The growth regulator herbicides 2,4-D and dicamba are used to control glyphosate-resistant horseweed before crops are planted. With the impending release of 2,4-D–resistant and dicamba-resistant crops, use of these growth regulator herbicides postemergence will likely increase. The objective of this study was to determine the effectiveness of various growth regulators on Indiana horseweed populations. A greenhouse dose–response study was conducted to evaluate the effectiveness of 2,4-D ester, diglycolamine salt of dicamba, and dimethylamine salt of dicamba on control of four populations of horseweed in the greenhouse. Population 66 expressed twofold levels of tolerance to 2,4-D ester and diglycolamine salt of dicamba. Population 43 expressed an enhanced level of tolerance to diglycolamine salt of dicamba but not to the other herbicides. Diglycolamine salt of dicamba provided the best overall control of populations 3 and 34. Additionally, a field study was conducted to evaluate standard use rates of 2,4-D amine, 2,4-D ester, diglycolamine salt of dicamba, and dimethylamine salt of dicamba on control of various sized glyphosate-resistant horseweed plants. Control of plants 30 cm or less in height was 90% or greater for all four herbicides. On plants greater than 30 cm tall, diglycolamine salt of dicamba provided 97% control while 2,4-D amine provided 81% control. Diglycolamine salt of dicamba provided the highest level of control of glyphosate-resistant horseweed, followed by dimethylamine salt of dicamba, 2,4-D ester and 2,4-D amine, respectively. This research demonstrates that horseweed populations respond differently to the various salts of 2,4-D and dicamba, and it will be important to determine the appropriate use rates of each salt to control glyphosate-resistant horseweed.
Management of Pigweed (Amaranthus spp.) in Glufosinate-Resistant Soybean in the Midwest and Mid-South
- Thomas R. Butts, Jason K. Norsworthy, Greg R. Kruger, Lowell D. Sandell, Bryan G. Young, Lawrence E. Steckel, Mark M. Loux, Kevin W. Bradley, Shawn P. Conley, David E. Stoltenberg, Francisco J. Arriaga, Vince M. Davis
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- Journal:
- Weed Technology / Volume 30 / Issue 2 / June 2016
- Published online by Cambridge University Press:
- 20 January 2017, pp. 355-365
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Pigweeds are among the most abundant and troublesome weed species across Midwest and mid-South soybean production systems because of their prolific growth characteristics and ability to rapidly evolve resistance to several herbicide sites of action. This has renewed interest in diversifying weed management strategies by implementing integrated weed management (IWM) programs to efficiently manage weeds, increase soybean light interception, and increase grain yield. Field studies were conducted across 16 site-years to determine the effectiveness of soybean row width, seeding rate, and herbicide strategy as components of IWM in glufosinate-resistant soybean. Sites were grouped according to optimum adaptation zones for soybean maturity groups (MGs). Across all MG regions, pigweed density and height at the POST herbicide timing, and end-of-season pigweed density, height, and fecundity were reduced in IWM programs using a PRE followed by (fb) POST herbicide strategy. Furthermore, a PRE fb POST herbicide strategy treatment increased soybean cumulative intercepted photosynthetically active radiation (CIPAR) and subsequently, soybean grain yield across all MG regions. Soybean row width and seeding rate manipulation effects were highly variable. Narrow row width (≤ 38 cm) and a high seeding rate (470,000 seeds ha−1) reduced end-of-season height and fecundity variably across MG regions compared with wide row width (≥ 76 cm) and moderate to low (322,000 to 173,000 seeds ha−1) seeding rates. However, narrow row widths and high seeding rates did not reduce pigweed density at the POST herbicide application timing or at soybean harvest. Across all MG regions, soybean CIPAR increased as soybean row width decreased and seeding rate increased; however, row width and seeding rate had variable effects on soybean yield. Furthermore, soybean CIPAR was not associated with end-of-season pigweed growth and fecundity. A PRE fb POST herbicide strategy was a necessary component for an IWM program as it simultaneously managed pigweeds, increased soybean CIPAR, and increased grain yield.
Herbicide Program Approaches for Managing Glyphosate-Resistant Palmer Amaranth (Amaranthus palmeri) and Waterhemp (Amaranthus tuberculatus and Amaranthus rudis) in Future Soybean-Trait Technologies
- Christopher J. Meyer, Jason K. Norsworthy, Bryan G. Young, Lawrence E. Steckel, Kevin W. Bradley, William G. Johnson, Mark M. Loux, Vince M. Davis, Greg R. Kruger, Mohammad T. Bararpour, Joseph T. Ikley, Douglas J. Spaunhorst, Thomas R. Butts
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- Journal:
- Weed Technology / Volume 29 / Issue 4 / December 2015
- Published online by Cambridge University Press:
- 20 January 2017, pp. 716-729
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Herbicide-resistant Amaranthus spp. continue to cause management difficulties in soybean. New soybean technologies under development, including resistance to various combinations of glyphosate, glufosinate, dicamba, 2,4-D, isoxaflutole, and mesotrione, will make possible the use of additional herbicide sites of action in soybean than is currently available. When this research was conducted, these soybean traits were still regulated and testing herbicide programs with the appropriate soybean genetics in a single experiment was not feasible. Therefore, the effectiveness of various herbicide programs (PRE herbicides followed by POST herbicides) was evaluated in bare-ground experiments on glyphosate-resistant Palmer amaranth and glyphosate-resistant waterhemp (both tall and common) at locations in Arkansas, Illinois, Indiana, Missouri, Nebraska, and Tennessee. Twenty-five herbicide programs were evaluated; 5 of which were PRE herbicides only, 10 were PRE herbicides followed by POST herbicides 3 to 4 wks after (WA) the PRE application (EPOST), and 10 were PRE herbicides followed by POST herbicides 6 to 7 WA the PRE application (LPOST). Programs with EPOST herbicides provided 94% or greater control of Palmer amaranth and waterhemp at 3 to 4 WA the EPOST. Overall, programs with LPOST herbicides resulted in a period of weed emergence in which weeds would typically compete with a crop. Weeds were not completely controlled with the LPOST herbicides because weed sizes were larger (≥ 15 cm) compared with their sizes at the EPOST application (≤ 7 cm). Most programs with LPOST herbicides provided 80 to 95% control at 3 to 4 WA applied LPOST. Based on an orthogonal contrast, using a synthetic-auxin herbicide LPOST improves control of Palmer amaranth and waterhemp over programs not containing a synthetic-auxin LPOST. These results show herbicides that can be used in soybean and that contain auxinic- or HPPD-resistant traits will provide growers with an opportunity for better control of glyphosate-resistant Palmer amaranth and waterhemp over a wide range of geographies and environments.
Growth and Seed Production of Horseweed (Conyza canadensis) Populations after Exposure to Postemergence 2,4-D
- Greg R. Kruger, Vince M. Davis, Stephen C. Weller, William G. Johnson
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- Journal:
- Weed Science / Volume 58 / Issue 4 / December 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 413-419
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Horseweed can be a problematic weed in no-till soybean fields and populations can vary in their response to 2,4-D. The objective of this study was to evaluate the growth and seed production of four horseweed populations after exposure to 2,4-D. 2,4-D amine was applied at 0, 140, 280, and 560 g ae ha−1 to 5- to 10-cm-tall horseweed plants. An additional treatment of 280 g ha−1 of 2,4-D + 840 g ae ha−1 of glyphosate was included in the study. At 2 wk after treatment (WAT), injury ranged from 47 to 98%, but by 6 WAT the injury ranged from 89 to 100% for all four populations. Between 6 and 12 WAT some individual horseweed plants started to recover. No differences in dry weights were observed between the four populations in the untreated checks at 0, 2, 6, and 12 WAT. At 280 g ha−1 of 2,4-D amine, seed production was reduced by greater than 95%. However, three of the four horseweed populations had plants that survived and produced seed after exposure to 840 g ha−1 of glyphosate + 280 g ha−1 of 2,4-D. One plant produced seed after exposure to 560 g ha−1 of 2,4-D. These results suggest that horseweed can evolve resistance to 2,4-D and no fitness penalities were observed in populations that had higher levels of tolerance to 2,4-D.
Growth and Seed Production of Horseweed (Conyza canadensis) Populations Resistant to Glyphosate, ALS-Inhibiting, and Multiple (Glyphosate + ALS-Inhibiting) Herbicides
- Vince M. Davis, Greg R. Kruger, Jeff M. Stachler, Mark M. Loux, William G. Johnson
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- Journal:
- Weed Science / Volume 57 / Issue 5 / October 2009
- Published online by Cambridge University Press:
- 20 January 2017, pp. 494-504
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Horseweed populations with mixtures of biotypes resistant to glyphosate and acetolactate synthase (ALS)–inhibiting herbicides as well as biotypes with multiple resistance to glyphosate + ALS-inhibiting herbicides have been documented in Indiana and Ohio. These biotypes are particularly problematic because ALS-inhibiting herbicides are commonly tank mixed with glyphosate to improve postemergence horseweed control in soybean. The objective of this research was to characterize the growth and seed production of horseweed populations with resistance to glyphosate or ALS-inhibiting herbicides, and multiple resistance to glyphosate + ALS-inhibiting herbicides. A four-herbicide by four-horseweed population factorial field experiment was conducted in the southeastern region of Indiana in 2007 and repeated in 2008. Four horseweed populations were collected from Indiana or Ohio and confirmed resistant to glyphosate, ALS inhibitors, both, or neither in greenhouse experiments. The four herbicide treatments were untreated, 0.84 kg ae ha−1 glyphosate, 35 g ai ha−1 cloransulam, and 0.84 kg ae ha−1 glyphosate + 35 g ai ha−1 cloransulam. Untreated plants from horseweed populations that were resistant to glyphosate, ALS-inhibiting, or multiple glyphosate + ALS-inhibiting herbicides produced similar amounts of biomass and seed compared to populations that were susceptible to those herbicides or combination of herbicides. Furthermore, aboveground shoot mass and seed production did not differ between treated and untreated plants.
Fall and Spring Preplant Herbicide Applications Influence Spring Emergence of Glyphosate-Resistant Horseweed (Conyza canadensis)
- Vince M. Davis, Greg R. Kruger, Bryan G. Young, William G. Johnson
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- Journal:
- Weed Technology / Volume 24 / Issue 1 / March 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 11-19
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Horseweed (Conyza canadensis) is a common weed in no-till crop production systems. It is problematic because of the frequent occurrence of biotypes resistant to glyphosate and acetolactate synthase (ALS)-inhibiting herbicides and its ability to complete its life cycle as a winter or summer annual weed. Tactics to control horseweed while controlling other winter annual weeds routinely fail; herbicide application timing and spring emergence patterns of horseweed may be responsible. The objectives of this experiment were to (1) determine the influence of fall and spring herbicides with and without soil residual horseweed activity on spring-emerging glyphosate-resistant (GR) horseweed density and (2) evaluate the efficacy and persistence of saflufenacil on GR horseweed. Field studies were conducted in southern Indiana and Illinois from fall 2006 to summer 2007 and repeated in 2007 to 2008. Six preplant herbicide treatments were applied at four application timings: early fall, late fall, early spring, and late spring. Horseweed plants were counted every 2 wk following the first spring application until the first week of July. Horseweed almost exclusively emerged in the spring at both locations. Spring horseweed emergence was higher when 2,4-D + glyphosate was fall-applied and controlled other winter annual weeds. With fall-applied 2,4-D + glyphosate, over 90% of the peak horseweed density was observed before April 25. In contrast, only 25% of the peak horseweed density was observed in the untreated check by April 25. Starting from the initiation of horseweed emergence in late March, chlorimuron + tribenuron applied early fall or early spring, and spring-applied saflufenacil at 100 g ai/ha provided greater than 90% horseweed control for 12 wk. Early spring–applied saflufenacil at 50 g ai/ha provided 8 wk of greater than 90% residual control, and early spring–applied simazine provided 6 wk of greater than 90% control. When applied in late spring, saflufenacil was the only herbicide treatment that reduced horseweed densities by greater than 90% compared to 2,4-D + glyphosate. We concluded from this research that fall applications of nonresidual herbicides can increase the rate and density of spring emerging horseweed. In addition, spring-applied saflufenacil provides no-till producers with a new preplant herbicide for foliar and residual control of glyphosate- and ALS-resistant horseweed.
Frequency, Distribution, and Characterization of Horseweed (Conyza canadensis) Biotypes with Resistance to Glyphosate and ALS-Inhibiting Herbicides
- Greg R. Kruger, Vince M. Davis, Stephen C. Weller, J. M. Stachler, M. M. Loux, William G. Johnson
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- Journal:
- Weed Science / Volume 57 / Issue 6 / December 2009
- Published online by Cambridge University Press:
- 20 January 2017, pp. 652-659
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Greenhouse studies were conducted to determine the prevalence of resistance to acetolactate synthase (ALS)-inhibiting herbicides in 266 Indiana horseweed populations, both glyphosate-susceptible and glyphosate-resistant, and to characterize the response of selected biotypes to combinations of glyphosate and cloransulam. Populations with individuals resistant to ALS inhibitors were more frequent in the northern half (38% of the populations in the NW and 50% of the populations in the NE) of Indiana than in the southern half (26% of the populations in the SW and 5% of the populations in the SE). Only 2% of the populations appeared to be resistant to both glyphosate and ALS inhibitors in an initial greenhouse study. Horseweed populations with resistance to ALS inhibitors exhibited herbicide doses required for 50% reduction in plant growth (GR50) values ranging from 14 to 255 g ai ha−1 of cloransulam. The resistant : susceptible (R : S) ratio for four horseweed populations with suspected resistance to glyphosate and ALS inhibitors ranged from 0.3 to 50 and from 2.5 to 8.1 for cloransulam and glyphosate, respectively. The tank mixtures exhibited an antagonistic response to 3 of the 16 combinations of cloransulam and glyphosate on the susceptible population. The tank mixtures exhibited primarily an additive response to those same combinations in the multiple-resistant populations, but the response was occasionally synergistic for two of the four populations. The additive response between glyphosate and cloransulam indicates that, where the level of resistance is fairly low, combinations of these herbicides should be more effective for control of multiple-resistant populations compared with application of a single herbicide.
Tall Waterhemp (Amaranthus tuberculatus) and Palmer amaranth (Amaranthus palmeri) Seed Production and Retention at Soybean Maturity
- Lauren M. Schwartz, Jason K. Norsworthy, Bryan G. Young, Kevin W. Bradley, Greg R. Kruger, Vince M. Davis, Larry E. Steckel, Michael J. Walsh
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- Journal:
- Weed Technology / Volume 30 / Issue 1 / March 2016
- Published online by Cambridge University Press:
- 20 January 2017, pp. 284-290
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Two of the most problematic Amaranthus species in soybean production today are tall waterhemp and Palmer amaranth. This study determined the percentage of tall waterhemp and Palmer amaranth seed that was retained by the weed at soybean maturity to assess the likelihood of using at-harvest weed seed control tactics for soil seedbank management. Palmer amaranth plants were collected from fields in Arkansas, Tennessee, Illinois, Missouri, and Nebraska, and tall waterhemp plants were collected from fields in Nebraska, Missouri, Wisconsin, and Illinois. Collected plants were assessed for at-harvest weed seed retention in 2013 and 2014. Within 1 wk of soybean maturity, Amaranthus plants were harvested and the loose soil and debris beneath the plants were swept into a pan with a hand broom to collect any shattered seed. Percent seed retention ranged from 95 to 100% for all states both years, regardless of species. There was a strong correlation between weed biomass (g) and total seed production (no. plant−1) in that the larger the plant, the more seeds it produced. However, there was no correlation between percent seed retention and weed biomass, which indicates that regardless of plant size and likely time of emergence, seed retention is high at the time of crop maturity. Overall, this study demonstrated that there is great opportunity for Palmer amaranth and tall waterhemp seed capture or destruction at soybean harvest. It is likely that nearly all of the seeds produced for both Amaranthus species passes through the combine during harvest to be returned to the soil seedbank. Thus, there is continued need for research focused on developing and testing harvest weed seed control tactics that aim at reducing the soil seedbank and lowering risks for evolution of herbicide resistance.
Heritability of Glyphosate Resistance in Indiana Horseweed (Conyza canadensis) Populations
- Vince M. Davis, Greg R. Kruger, Steven G. Hallett, Patrick J. Tranel, William G. Johnson
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- Journal:
- Weed Science / Volume 58 / Issue 1 / March 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 30-38
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Horseweed has rapidly become a major weed in soybean and cotton production fields of the United States, and Indiana farmers ranked horseweed as one of the five worst weeds in their fields during a mail survey in 2003. Glyphosate resistance in horseweed is conferred by a single, incompletely dominant gene. Horseweed populations possess a high level of variability in their response to glyphosate. Horseweed has also evolved resistance to acetolactate synthase (ALS) inhibitors, and biotypes resistant to ALS-inhibiting herbicides and glyphosate are in many of the same areas. An experiment was designed to determine whether glyphosate resistance can be transferred by pollen. We found glyphosate-resistant plants in 1.1 to 3.8% of the progeny. Segregation ratios fit the expected 3 : 1 resistant : sensitive ratios confirming that glyphosate resistance in horseweed can transfer to closely located glyphosate-susceptible biotypes under open-pollinated conditions at low frequencies. The hypothesis of a follow-up experiment was that first-generation progeny of parent plants, selected on a continuum of low to high phenotypic response to glyphosate, will inherit respective low to high phenotypic responses to glyphosate. The variability in field-collected populations (low-level to high-level glyphosate resistance) ranged from 2 to 14 times the commonly recommended field use rate of glyphosate. However, low- and high-levels of glyphosate resistance were not observed in first-generation progeny. We conclude that differential glyphosate responses observed among parental populations was due to different frequencies of the resistance allele within the populations, rather than the presence of different resistance alleles.
Early-Season Palmer Amaranth and Waterhemp Control from Preemergence Programs Utilizing 4-Hydroxyphenylpyruvate Dioxygenase–Inhibiting and Auxinic Herbicides in Soybean
- Christopher J. Meyer, Jason K. Norsworthy, Bryan G. Young, Lawrence E. Steckel, Kevin W. Bradley, William G. Johnson, Mark M. Loux, Vince M. Davis, Greg R. Kruger, Mohammad T. Bararpour, Joseph T. Ikley, Douglas J. Spaunhorst, Thomas R. Butts
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- Journal:
- Weed Technology / Volume 30 / Issue 1 / March 2016
- Published online by Cambridge University Press:
- 20 January 2017, pp. 67-75
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Palmer amaranth and waterhemp have become increasingly troublesome weeds throughout the United States. Both species are highly adaptable and emerge continuously throughout the summer months, presenting the need for a residual PRE application in soybean. To improve season-long control of Amaranthus spp., 19 PRE treatments were evaluated on glyphosate-resistant Palmer amaranth in 2013 and 2014 at locations in Arkansas, Indiana, Nebraska, Illinois, and Tennessee; and on glyphosate-resistant waterhemp at locations in Illinois, Missouri, and Nebraska. The two Amaranthus species were analyzed separately; data for each species were pooled across site-years, and site-year was included as a random variable in the analyses. The dissipation of weed control throughout the course of the experiments was compared among treatments with the use of regression analysis where percent weed control was described as a function of time (the number of weeks after treatment [WAT]). At the mean (i.e., average) WAT (4.3 and 3.2 WAT for Palmer amaranth and waterhemp, respectively) isoxaflutole + S-metolachlor + metribuzin had the highest predicted control of Palmer amaranth (98%) and waterhemp (99%). Isoxaflutole + S-metolachlor + metribuzin, S-metolachlor + mesotrione, and flumioxazin + pyroxasulfone had a predicted control ≥ 97% and similar model parameter estimates, indicating control declined at similar rates for these treatments. Dicamba and 2,4-D provided some, short-lived residual control of Amaranthus spp. When dicamba was added to metribuzin or S-metolachlor, control increased compared to dicamba alone. Flumioxazin + pyroxasulfone, a currently labeled PRE, performed similarly to treatments containing isoxaflutole or mesotrione. Additional sites of action will provide soybean growers more opportunities to control these weeds and reduce the potential for herbicide resistance.
Response and Survival of Rosette-Stage Horseweed (Conyza canadensis) after Exposure to 2,4-D
- Greg R. Kruger, Vince M. Davis, Stephen C. Weller, William G. Johnson
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- Journal:
- Weed Science / Volume 56 / Issue 5 / October 2008
- Published online by Cambridge University Press:
- 20 January 2017, pp. 748-752
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2,4-D is often used as a preplant burndown herbicide to help control horseweed and other broadleaf weeds before planting in no-till corn and soybean production. Isolated instances of poor horseweed control have occurred in production fields. The objective of this research was to evaluate the response of various horseweed populations to 2,4-D. In the first study, 478 horseweed populations from Indiana were subjected to 280 g ae ha−1 of 2,4-D amine in the greenhouse. This rate of 2,4-D caused visible injury and prevented all biotypes from forming new leaves for 28 days. There were specific populations where all plants sprayed were alive at 28 days after treatment (DAT), and approximately 10% of all populations had a least one plant that survived 280 g ae ha−1 2,4-D, resumed growth, and produced seed. In a dose-response study, we observed populations with three-fold more tolerance to 2,4-D. The most tolerant population had a GR90 of 513 g ae ha−1 and the most susceptible population had a GR90 of 121 g ae ha−1 based on dry weights. Growth suppression with 2,4-D was not affected by rosette size for rosettes between 0.5 and 10 cm in width.
Novel Superconducting Joints for Persistent Mode Magnet Applications
- Tayebeh Mousavi, William Darby, Canan Aksoy, Timothy Davies, Greg Brittles, Chris Grovenor, Susannah Speller
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- Journal:
- MRS Advances / Volume 1 / Issue 51 / 2016
- Published online by Cambridge University Press:
- 10 June 2016, pp. 3483-3488
- Print publication:
- 2016
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Persistent current joints are a critical component of commercial superconducting magnets.The standard jointing method widely used in the magnet industry for technological low temperature superconducting wires such as NbTi and Nb3Sn wires uses a superconducting solder (e.g. PbBi). In these joints the physical and superconducting properties of the solder materials inevitably play an important role in the overall performance of the joint. Key requirements for superconducting solders include low melting point to prevent degradation of the superconducting filaments during joining, good wettability of the superconducting filaments, suitable liquid phase viscosity, and finally adequate superconducting properties to enable sufficient supercurrent to pass through the joint under typical operating conditions (typically at 4.2K in a field of 1 T for an MRI magnet). PbBi solder satisfies all these criteria, but restrictions on the use of lead in the magnet industry are expected in the relatively near future, so new lead-free jointing techniques need to be developed.
One approach is the development of superconducting lead-free solder materials. In our work, we have focussed on the In-Sn system and ternary systems involving In and Sn as two of the elements. Thermodynamic modelling has been used to produce ternary phase diagrams of potential alloy systems, and various formulations have been fabricated in order to explore how microstructure and phase chemistry influence the superconducting properties of the solders. Alternative approaches to fabricating lead-free joints, including spot welding and cold-pressing, have also been investigated. These methods have the potential advantage of achieving direct NbTi-NbTi joints with no intermediate, lower performance superconducting material. The spot welding method produced joints with the best superconducting performance, signifiantly better than the currently used PbBi solder, but the lack of reproducibility in this technique may be a problem from an industrial point of view.
Contributors
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- By Waiel Almoustadi, Brian J. Anderson, David B. Auyong, Michael Avidan, Michael J. Avram, Roland J. Bainton, Jeffrey R. Balser, Juliana Barr, W. Scott Beattie, Manfred Blobner, T. Andrew Bowdle, Walter A. Boyle, Eugene B. Campbell, Laura F. Cavallone, Mario Cibelli, C. Michael Crowder, Ola Dale, M. Frances Davies, Mark Dershwitz, George Despotis, Clifford S. Deutschman, Brian S. Donahue, Marcel E. Durieux, Thomas J. Ebert, Talmage D. Egan, Helge Eilers, E. Wesley Ely, Charles W. Emala, Alex S. Evers, Heidrun Fink, Pierre Foëx, Stuart A. Forman, Helen F. Galley, Josephine M. Garcia-Ferrer, Robert W. Gereau, Tony Gin, David Glick, B. Joseph Guglielmo, Dhanesh K. Gupta, Howard B. Gutstein, Robert G. Hahn, Greg B. Hammer, Brian P. Head, Helen Higham, Laureen Hill, Kirk Hogan, Charles W. Hogue, Christopher G. Hughes, Eric Jacobsohn, Roger A. Johns, Dean R. Jones, Max Kelz, Evan D. Kharasch, Ellen W. King, W. Andrew Kofke, Tom C. Krejcie, Richard M. Langford, H. T. Lee, Isobel Lever, Jerrold H. Levy, J. Lance Lichtor, Larry Lindenbaum, Hung Pin Liu, Geoff Lockwood, Alex Macario, Conan MacDougall, M. B. MacIver, Aman Mahajan, Nándor Marczin, J. A. Jeevendra Martyn, George A. Mashour, Mervyn Maze, Thomas McDowell, Stuart McGrane, Berend Mets, Patrick Meybohm, Charles F. Minto, Jonathan Moss, Mohamed Naguib, Istvan Nagy, Nick Oliver, Paul S. Pagel, Pratik P. Pandharipande, Piyush Patel, Andrew J. Patterson, Robert A. Pearce, Ronald G. Pearl, Misha Perouansky, Kristof Racz, Chinniampalayam Rajamohan, Nilesh Randive, Imre Redai, Stephen Robinson, Richard W. Rosenquist, Carl E. Rosow, Uwe Rudolph, Francis V. Salinas, Robert D. Sanders, Sunita Sastry, Michael Schäfer, Jens Scholz, Thomas W. Schnider, Mark A. Schumacher, John W. Sear, Frédérique S. Servin, Jeffrey H. Silverstein, Tom De Smet, Martin Smith, Joe Henry Steinbach, Markus Steinfath, David F. Stowe, Gary R. Strichartz, Michel M. R. F. Struys, Isao Tsuneyoshi, Robert A. Veselis, Arthur Wallace, Robert P. Walt, David C. Warltier, Nigel R. Webster, Jeanine Wiener-Kronish, Troy Wildes, Paul Wischmeyer, Ling-Gang Wu, Stephen Yang
- Edited by Alex S. Evers, Washington University School of Medicine, St Louis, Mervyn Maze, University of California, San Francisco, Evan D. Kharasch, Washington University School of Medicine, St Louis
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- Book:
- Anesthetic Pharmacology
- Published online:
- 11 April 2011
- Print publication:
- 10 March 2011, pp viii-xiv
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28 - Tier 4 options
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- By Tim McDougall, Lead Nurse, Cheshire & Wirral NHS Foundation Trust, Anne Worrall-Davies, MBChB, MMedSc, MRCPsych, Senior Lecturer in Child and Adolescent Psychiatry, University of Leeds, and Honorary Consultant in Child and Adolescent Psychiatry, NHS Leeds, Lesley Hewson, MBChB, MRCPsych, FRCPsych, Consultant Child and Adolescent Psychiatrist, Bradford District Care Trust, Rosie Beer, Retired Consultant in Child and Adolescent Psychiatry, Leeds, Greg Richardson, MBChB, DCH, DPM, FRCPsych, Consultant Child and Adolescent Psychiatrist, Lime Trees CAMHS, North Yorkshire & York Primary Care Trust
- Edited by Greg Richardson, Ian Partridge, Jonathan Barrett
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- Book:
- Child and Adolescent Mental Health Services
- Published online:
- 02 January 2018
- Print publication:
- 01 February 2010, pp 259-269
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Summary
‘Two roads diverged in a wood, and I–
I took the one less travelled by,
And that has made all the difference.’
Robert Frost (1874–1963)Introduction
Tier 4 CAMHS aim to meet the needs of children and young people with the most complex, severe or persistent mental health problems. Tier 4 services include in-patient care (see Chapter 29), as well as a range of day care and intensive community home-based and outreach services for specific groups of children and young people.
Day services
Early descriptions of child and adolescent mental health day units emphasised 5-day ‘milieu’ provision with a strong emphasis on education and behaviour management (Brown, 1996), whereas now they frequently provide daily focused activities to which children and families are invited, depending on their needs. Currently, about half of UK day services are linked to in-patient units, and many in-patient units have a day programme (Green & Jacobs, 1998). It is impossible to classify day services owing to the enormous range in milieu and interventions provided (Green & Worrall- Davies, 2008). However, day services broadly offer:
• support and transition to community services following in-patient admission;
• intensive 5 days per week treatment packages for children and their families;
• treatment of disruptive behaviour, using multimodal treatment strategies with a combination of individual, family and psychopharmacological interventions;
• specialist management and programmes of care for younger children with developmental disorders such as autism, speech and language disorders or neuropsychiatric disorders;
• intensive intervention aimed at improving family functioning in situations of family breakdown or child maltreatment.
Provision and organisation
Day units can offer assessment and therapeutic services that are more specialised, complex and intensive than out-patient services, although they are still community-based and less disruptive than in-patient admission. Most also have the benefit of educational input. Close liaison with specialised education and Social Services is central to their work. There is general acceptance of the central importance of maintaining attachments and working with whole systems if the complex needs of children are to be met. Day units can work with children and young people individually and in groups, as well as with their families, while keeping the focus of concern within the community and avoiding the ‘out of sight, out of mind’ dilemma of in-patient services.